The Two Main Protocols

Fadiman Protocol (Most Popular)

Day 1: Dose. Day 2: Transition. Day 3: Rest. Repeat.

This gives your brain time to integrate each dose before the next one. Most users report this prevents tolerance buildup.

Stamets Stack (Most Studied for Neuroplasticity)

5 days on, 2 days off. Includes Lion's Mane + Niacin to enhance the neuroplasticity effect.

Starting Dose

Start at the lowest dose available. The goal is sub-perceptual — you should feel nothing unusual, just a subtle lift in mood and focus.

What to Track

Daily log: mood (1-10), energy (1-10), focus (1-10), sleep quality, notable experiences. After 4 weeks, you'll have enough data to optimize your protocol.

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