Psilocybin Microdosing Protocols: Fadiman vs Stamets vs Every Day
The three most common microdosing protocols differ in frequency, dose, and purpose. Here's a direct comparison to help you choose the right approach.
The Short Answer
The three most common microdosing protocols are: Fadiman (1 day on, 2 days off — the most studied), Stamets (4 days on, 3 days off — includes lion's mane and niacin), and Every Day (daily — not recommended due to rapid tolerance development). The Fadiman protocol is the most commonly recommended starting point because it allows clear comparison between microdosing and non-microdosing days, prevents tolerance, and has the most observational data.
Protocol Comparison
| Protocol | Schedule | Dose | Best For |
|---|---|---|---|
| Fadiman | Day 1 on, Day 2-3 off | 0.1–0.3g | General use, beginners |
| Stamets | 4 days on, 3 days off | 0.1–0.2g + lion's mane + niacin | Neuroplasticity, cognitive enhancement |
| Every Day | Daily | 0.05–0.1g | Not recommended (tolerance) |
| Intuitive | As needed | Variable | Experienced users only |
The Fadiman Protocol
Developed by James Fadiman based on observational data from hundreds of self-reporters. The 1-on, 2-off schedule prevents tolerance (psilocybin tolerance develops within 24–48 hours) and allows clear comparison between microdosing and non-microdosing days for tracking effects.
The Stamets Protocol
Developed by mycologist Paul Stamets. Adds lion's mane mushroom (for NGF stimulation) and niacin (as a "flush" to drive the compounds into the nervous system) to psilocybin. The 4-on, 3-off schedule is more aggressive. Stamets claims synergistic neuroplasticity effects from the combination.
Which Protocol to Start With
For most people, the Fadiman protocol is the best starting point. It is the most studied, the most forgiving, and provides the clearest feedback on effects. Start at 0.1g and adjust based on response.
This article is for informational purposes only and does not constitute medical advice.
This article is for informational purposes only and does not constitute medical advice. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your physician before making any changes to your health regimen.