The Stamets Stack: Psilocybin + Lion's Mane + Niacin Protocol Explained

Paul Stamets' microdosing stack combines psilocybin, Lion's Mane mushroom, and niacin for enhanced neuroplasticity. Here's the science and how to use it.

The Stamets Stack: Psilocybin + Lion's Mane + Niacin

Direct Answer: The Stamets Stack combines psilocybin (0.1–0.3g), Lion's Mane mushroom (500–1000mg), and niacin (100–200mg) on a 5-days-on, 2-days-off schedule. The theory is that these three compounds synergistically enhance neuroplasticity.

The Rationale

Psilocybin: Activates 5-HT2A receptors, promotes BDNF, disrupts DMN. Lion's Mane: Promotes Nerve Growth Factor (NGF), supporting neuron growth. Niacin: Vasodilator that may help deliver the other compounds across the blood-brain barrier.

The Schedule

5 days on, 2 days off (typically weekdays on, weekends off). More intensive than the Fadiman Protocol — better for people seeking maximum neuroplasticity effects.

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FAQ

Is the Stamets Stack better than the Fadiman Protocol?

It's more intensive and theoretically more neuroplastic. But it's also more complex and may cause more side effects (niacin flush). The Fadiman Protocol is better for beginners.

Research Hub

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