Microdosing for ADHD: What the Research Shows

## The Overlap Between ADHD and Depression ADHD and depression co-occur at high rates — approximately 50% of adults with ADHD also have a depressive disorder. Both involve dysregulation of the default mode network, difficulty with emotional regulation, and both respond to interventions that promote neuroplasticity. ## What the Survey Data Shows A 2019 survey of 1,116 microdosers found that ADHD was the second most common reason for microdosing (after depression). A 2021 survey specifically examining microdosing for ADHD found that 80% of ADHD microdosers reported improvements in focus and concentration, and 67% reported reduced impulsivity. ## The Proposed Mechanism The default mode network (DMN) is overactive in both ADHD and depression. In ADHD, this manifests as mind-wandering, difficulty sustaining attention, and intrusive thoughts. Psilocybin reduces DMN rigidity, which may explain why it helps with both conditions. ## Microdosing and ADHD Medication There are no documented dangerous interactions between psilocybin at microdosing doses and stimulant medications. However, both affect serotonin and dopamine systems, and the combination can feel overstimulating for some people. Starting on a day when you're not taking stimulants is a reasonable approach. [See the protocol →](/research-checkout) *This article is for informational purposes only and does not constitute medical advice.*