How to Microdose Mushrooms: The Complete Protocol Guide

## The Two Main Protocols ### The Fadiman Protocol **Schedule:** 1 day on, 2 days off (repeat). Example: dose Monday, off Tuesday-Wednesday, dose Thursday, off Friday-Saturday, dose Sunday. **Why the off-days matter:** Psilocybin builds tolerance quickly. The 2-day gap allows your 5-HT2A receptors to reset, maintaining the neuroplasticity effect. **Typical dose:** 0.1–0.3g dried psilocybin mushrooms. ### The Stamets Protocol **Schedule:** 4 days on, 3 days off (repeat). Combines psilocybin with lion's mane mushroom and niacin (vitamin B3). **Typical dose:** 0.1–0.2g psilocybin + lion's mane + niacin. ## Starting Dose Start lower than you think you need. Most people start at 0.2g and find it's too stimulating. - Week 1: 0.1g (find your baseline) - Week 2: 0.15g (if week 1 felt too subtle) - Week 3+: 0.2g (standard dose) A true microdose should be sub-perceptual — you should not feel altered. ## What to Expect **Days 1–7:** Subtle. Slightly better focus, more emotional flexibility. Some people notice nothing in week 1 — normal. **Days 7–21:** Neuroplasticity effects accumulate. Reduced rumination, improved mood stability, better sleep. **Days 21–60:** Full protocol effect. Mood improvements consistent and stable. ## Common Mistakes 1. Dosing too high — causes stimulation or anxiety 2. Not tracking — keep a simple daily journal 3. Expecting immediate results — give it 4–6 weeks 4. Dosing on high-stress days — microdosing amplifies the emotional texture of your day [Get the full protocol →](/research-checkout) *This article is for informational purposes only and does not constitute medical advice.*