The Fadiman Protocol: The Most Studied Microdosing Schedule Explained

The Fadiman Protocol — one day on, two days off — is the most researched microdosing schedule. Here's how it works and why it's designed this way.

The Fadiman Protocol: The Most Studied Microdosing Schedule

Direct Answer: The Fadiman Protocol is: Day 1 (dose day), Day 2 (transition day — effects still present but fading), Day 3 (normal day), then repeat. This schedule prevents tolerance buildup while allowing the brain to integrate the effects between doses.

Why This Schedule Works

Psilocybin builds tolerance rapidly — taking it daily would require increasing doses. The two-day gap prevents tolerance while maintaining consistent benefits. The "transition day" is often reported as one of the best days — the direct effects have passed, but the neuroplasticity window is open.

Who It's Best For

Beginners, people with depression or anxiety, and those seeking consistent mood and cognitive benefits. The predictable schedule makes it easy to plan around work and social commitments.

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FAQ

Can I adjust the Fadiman Protocol?

Yes. Many people modify it based on their response — some prefer every 4 days, others every 2 days. The key principle is having regular off-days to prevent tolerance.

Research Hub

Psilocybin & Microdosing Research Hub

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