Can Psilocybin Help With OCD?
Direct Answer: Early evidence is very promising. A University of Arizona study found psilocybin reduced OCD symptoms by 23–100% in all 9 participants.
The University of Arizona OCD Study
2006 study: all 9 participants showed significant reductions, ranging from 23% to 100%, effects persisted beyond the session, no serious adverse events.
Why Psilocybin May Help OCD
OCD involves hyperactivity in the brain's "checking" loop. Psilocybin's serotonin 2A agonism may produce more direct effects than SSRIs, while its cognitive flexibility increase directly addresses OCD's rigid, repetitive thinking.
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Can microdosing help with OCD?
Many people with OCD report benefits from microdosing, including reduced intrusive thoughts and compulsive urges.
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Psilocybin & Microdosing Research Hub
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